Inhibition of gap junctional intercellular communication by toxic metals.
Identifieur interne : 001905 ( Main/Exploration ); précédent : 001904; suivant : 001906Inhibition of gap junctional intercellular communication by toxic metals.
Auteurs : RBID : pubmed:20866040English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Connexins.
- drug effects : Cell Communication, Gap Junctions.
- physiology : Cell Communication, Gap Junctions.
- chemical , toxicity : Environmental Pollutants, Metals.
- Humans.
Abstract
As metals are ubiquitous in the environment, humans are continuously exposed to them. Although some metallic ions play key roles in human physiology, most metals are redundant and are actually hazardous to humans. A frequent event in the toxicological cascade triggered by nonessential metals concerns the abrogation of cellular signaling mediated by gap junctions. This paper provides a literature overview of the documented effects of mercury, cadmium, arsenic, aluminum, lead, nickel, vanadium, and indium on gap junctional intercellular communication. Whenever available, particular attention is paid to the mechanistic basis of this deleterious biological outcome, which may involve the gap junction activity level or may arise from modifications in the expression of the gap junction building stones, the connexins.
DOI: 10.1021/tx100276f
PubMed: 20866040
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Inhibition of gap junctional intercellular communication by toxic metals.</title><author><name sortKey="Vinken, Mathieu" uniqKey="Vinken M">Mathieu Vinken</name><affiliation wicri:level="1"><nlm:affiliation>Department of Toxicology, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium. mvinken@vub.ac.be</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Toxicology, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels</wicri:regionArea></affiliation></author><author><name sortKey="Ceelen, Liesbeth" uniqKey="Ceelen L">Liesbeth Ceelen</name></author><author><name sortKey="Vanhaecke, Tamara" uniqKey="Vanhaecke T">Tamara Vanhaecke</name></author><author><name sortKey="Rogiers, Vera" uniqKey="Rogiers V">Vera Rogiers</name></author></titleStmt><publicationStmt><date when="2010">2010</date><idno type="doi">10.1021/tx100276f</idno><idno type="RBID">pubmed:20866040</idno><idno type="pmid">20866040</idno><idno type="wicri:Area/Main/Corpus">001772</idno><idno type="wicri:Area/Main/Curation">001772</idno><idno type="wicri:Area/Main/Exploration">001905</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cell Communication (drug effects)</term><term>Cell Communication (physiology)</term><term>Connexins (metabolism)</term><term>Environmental Pollutants (toxicity)</term><term>Gap Junctions (drug effects)</term><term>Gap Junctions (physiology)</term><term>Humans</term><term>Metals (toxicity)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Connexins</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Communication</term><term>Gap Junctions</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cell Communication</term><term>Gap Junctions</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Environmental Pollutants</term><term>Metals</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">As metals are ubiquitous in the environment, humans are continuously exposed to them. Although some metallic ions play key roles in human physiology, most metals are redundant and are actually hazardous to humans. A frequent event in the toxicological cascade triggered by nonessential metals concerns the abrogation of cellular signaling mediated by gap junctions. This paper provides a literature overview of the documented effects of mercury, cadmium, arsenic, aluminum, lead, nickel, vanadium, and indium on gap junctional intercellular communication. Whenever available, particular attention is paid to the mechanistic basis of this deleterious biological outcome, which may involve the gap junction activity level or may arise from modifications in the expression of the gap junction building stones, the connexins.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">20866040</PMID><DateCreated><Year>2011</Year><Month>10</Month><Day>05</Day></DateCreated><DateCompleted><Year>2012</Year><Month>03</Month><Day>20</Day></DateCompleted><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1520-5010</ISSN><JournalIssue CitedMedium="Internet"><Volume>23</Volume><Issue>12</Issue><PubDate><Year>2010</Year><Month>Dec</Month><Day>20</Day></PubDate></JournalIssue><Title>Chemical research in toxicology</Title><ISOAbbreviation>Chem. Res. Toxicol.</ISOAbbreviation></Journal><ArticleTitle>Inhibition of gap junctional intercellular communication by toxic metals.</ArticleTitle><Pagination><MedlinePgn>1862-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1021/tx100276f</ELocationID><Abstract><AbstractText>As metals are ubiquitous in the environment, humans are continuously exposed to them. Although some metallic ions play key roles in human physiology, most metals are redundant and are actually hazardous to humans. A frequent event in the toxicological cascade triggered by nonessential metals concerns the abrogation of cellular signaling mediated by gap junctions. This paper provides a literature overview of the documented effects of mercury, cadmium, arsenic, aluminum, lead, nickel, vanadium, and indium on gap junctional intercellular communication. Whenever available, particular attention is paid to the mechanistic basis of this deleterious biological outcome, which may involve the gap junction activity level or may arise from modifications in the expression of the gap junction building stones, the connexins.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vinken</LastName><ForeName>Mathieu</ForeName><Initials>M</Initials><Affiliation>Department of Toxicology, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium. mvinken@vub.ac.be</Affiliation></Author><Author ValidYN="Y"><LastName>Ceelen</LastName><ForeName>Liesbeth</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Vanhaecke</LastName><ForeName>Tamara</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Rogiers</LastName><ForeName>Vera</ForeName><Initials>V</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, Non-U.S. Gov't</PublicationType><PublicationType>Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>09</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Chem Res Toxicol</MedlineTA><NlmUniqueID>8807448</NlmUniqueID><ISSNLinking>0893-228X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Connexins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Environmental Pollutants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Metals</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Cell Communication</DescriptorName><QualifierName MajorTopicYN="Y">drug effects</QualifierName><QualifierName MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Connexins</DescriptorName><QualifierName MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Environmental Pollutants</DescriptorName><QualifierName MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Gap Junctions</DescriptorName><QualifierName MajorTopicYN="Y">drug effects</QualifierName><QualifierName MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Metals</DescriptorName><QualifierName MajorTopicYN="Y">toxicity</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="aheadofprint"><Year>2010</Year><Month>9</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>9</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>9</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>3</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1021/tx100276f</ArticleId><ArticleId IdType="pubmed">20866040</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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